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Twin compartments that run the length of the penis, called corpora cavernosa, become flush with blood that is trapped in the shaft.

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It is also worth noting that many medications used for the treatment of depression and other psychiatric disorders may cause erectile dysfunction or ejaculatory problems. Readers Comments 1 Share Your Story Advanced age Cardiovascular disease Hypertension Diabetes mellitus High cholesterol Cigarette smoking Recreational drug use Depression or other psychiatric disorders Pelvic surgery, including radical prostatectomy and colorectal surgery Pelvic radiation, such as for prostate cancer and some colorectal cancers Trauma to the pelvis (pelvic fracture), penis (penile fracture), and perineum QUESTION Erectile dysfunction (ED) is… See Answer
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ED is a potentially treatable medical condition and is not related to masculinity or sexual prowess. Men who have ED symptoms should consult with a doctor.
More than half of men will grapple with ED during their lives. Though the condition does affect more older men than younger men — half of the erectile dysfunction patients in the U.S. are over the age of 60 — men who suffer from ED span age groups. Five percent of men under age 40 have complete ED and can’t achieve an erection without treatment. If any of this describes you, then you’re not alone at all. ED is a common condition. One recent study estimated that roughly a third of men struggle with ED to some degree.

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Exercises should not cause any pain whatsoever. If you do experience pain, stop the exercises immediately, and seek medical help.
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An imbalance in your hormones, such as testosterone, prolactin, or thyroid, can cause erectile dysfunction. The following hormonal (or endocrine) conditions are commonly associated with erectile dysfunction:Hyperthyroidism (overactive thyroid gland)Hypothyroidism (underactive thyroid gland)Hypogonadism (leads to lower testosterone levels) Bad Bugs and Their Bites Sex Drive Killers Cancerous Tumors Multiple Sclerosis Adult Skin Problems Habits That Wreck Your Teeth Manage Diabetes in 10 Minutes Erectile Dysfunction Type 2 Diabetes Warning Signs Health Benefits of Sex Scalp, Hair and Nails ADHD Symptoms in Children?

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When the amount of cGMP decreases by the action of a chemical called phosphodiesterase type 5 (PDE5), the muscles in the penis tighten, and the blood flows into the penis decreases. With less blood coming into the penis, the veins are not compressed, allowing blood to drain out of the penis, and the erection goes down. Penile erection occurs, but the penis does not remain hard enough for the completion of sex. Penile erections are not hard enough for penetration. There is an inability to obtain a penile erection. One can still achieve an orgasm and ejaculate with erectile dysfunction. FDA Mulling OTC Sale of Contraceptive Pills U.S. HPV Vaccination Rates Rising, Even Among Boys No Change in Recent Decades in Infertility Rate HPV 'Herd Immunity' Now Helping Women Underwear Guards Against STDs During Oral Sex Daily Health News CDC Investigates E. coli Outbreak Death From Brain-Eating Amoeba DNA Tied to Autism, Other Disorders 10 Warning Signs of Parkinson's Same-Day Test Spots Miscarriage Risk More Health News » Trending on MedicineNet Triple-Negative Breast Cancer Causes of Stool Color Changes Good Heart Rate By Age Laminectomy Recovery Time Normal Blood Pressure By Age Read Doctor's View Readers Comments 2 Share Your Story A healthy nervous system that conducts nerve impulses in the brain, spinal column, and penis Healthy arteries in and near the corpora cavernosa that when stimulated can bring increased blood flow into the penis Healthy muscles and fibrous tissues within the corpora cavernosa, can distend to allow the penis to fill with blood Adequate levels of nitric oxide in the penis Normal-functioning tunica albuginea that allows for compression of the veins Appropriate psychosocial interactions

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    Patients should start with a low dose and increase in small doses until the dose that results in a rigid enough erection for completion of sexual activity is achieved. If one injects and there is an inadequate response, one should not reinject another dose of the medication at that time, due to the risk of priapism.

    The authors would like to acknowledge the University of Gondar for its support and facilitation of the study. The authors also want to thank all the study participants for their collaboration and participation in the study. 1. Gebreyohannes EA, Bhagavathula AS, Gebresillassie BM, Tefera YG, Belachew SA, Erku DA. Recreational use of phosphodiesterase 5 inhibitors and its associated factors among undergraduate male students in an Ethiopian University: a cross-sectional study. World J Mens Health. (2016) 34:186–93. doi: 10.5534/wjmh.2016.34.3.186 2. Guay AT, Perez JB, Jacobson J, Newton RA. Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors. J Androl. (2001) 22:793–7. Erratum in: J Androl. (2002) 23:113. doi: 10.1002/j.1939-4640.2001.tb02582.x 3. Harte CB, Meston CM. Recreational use of erectile dysfunction medications and its adverse effects on erectile function in young healthy men: the mediating role of confidence in erectile ability. J Sex Med. (2012) 9:1852–9. doi: 10.1111/j.1743-6109.2012.02755.x 4. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol. (1999) 83:35C−44C. doi: 10.1016/S0002-9149(99)00046-6 5. Delate T, Simmons VA, Motheral BR. Patterns of use of sildenafil among commercially insured adults in the United States: 1998-2002. Int J Impot Res. (2004) 16:313–8. doi: 10.1038/sj.ijir.3901191 6. Bechara A, Casabé A, De Bonis W, Helien A, Bertolino MV. Recreational use of phosphodiesterase type 5 inhibitors by healthy young men. J Sex Med. (2010) 7:3736–42. doi: 10.1111/j.1743-6109.2010.01965.x 7. Makwana S, Solanki M., Raloti S., Dikshit R. Evaluation of recreational use of aphrodisiac drugs and its consequences: an online questionnaire based study. Int J Res Med. (2013) 1:51–9. 8. Harte CB, Meston CM. Recreational use of erectile dysfunction medications in undergraduate men in the United States: characteristics and associated risk factors. Arch Sex Behav. (2011) 40:597–606. doi: 10.1007/s10508-010-9619-y 9. Schnetzler G, Banks I, Kirby M, Zou KH, Symonds T. Characteristics, behaviors, and attitudes of men bypassing the healthcare system when obtaining phosphodiesterase type 5 inhibitors. J Sex Med. (2010) 7:1237–46. doi: 10.1111/j.1743-6109.2009.01674.x 10. Gebregeorgise DT, Belay YM, Kälvemark Sporrong S. Sildenafil citrate use in Addis Ababa: characteristics of users and pharmacists' dispensing practices. Int J Clin Pharm. (2018) 40:67–73. doi: 10.1007/s11096-017-0558-8 11. Both R. Sex, tension, and pills: young people's use of contemporary reproductive and sexual health technologies in Addis Ababa, Ethiopia (Doctoral dissertation). Anthropology Department, University of Amsterdam, Amsterdam, Netherland (2017). Available online at: https://pure.uva.nl/ws/files/9794196/Thesis_complete_.pdf 12. Both R. A matter of sexual confidence: young men's non-prescription use of Viagra in Addis Ababa, Ethiopia. Cult Health Sex. (2016) 18:495–508. doi: 10.1080/13691058.2015.1101489 13. Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr, et al. Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee. Circulation. (1999) 99:168–77. doi: 10.1161/01.CIR.99.1.168 14. Santtila P, Sandnabba NK, Jern P, Varjonen M, Witting K, von der Pahlen B. Recreational use of erectile dysfunction medication may decrease confidence in ability to gain and hold erections in young males. Int J Impot Res. (2007) 19:591–6. doi: 10.1038/sj.ijir.3901584 15. Schiefer J, Sparing R. Transient global amnesia after intake of tadalafil, a PDE-5 inhibitor: a possible association? Int J Impot Res. (2005) 17:383–4. doi: 10.1038/sj.ijir.3901301 16. Pomara G, Morelli G, Menchini-Fabris F, Dinelli N, Campo G, LiGuori G, et al. Epistaxis after PDE-5 inhibitors misuse. Int J Impot Res. (2006) 18:213–4. doi: 10.1038/sj.ijir.3901383 17. Tiryakioglu SK, Tiryakioglu O, Turan T, Kumbay E. Aortic dissection due to sildenafil abuse. Interact Cardiovasc Thorac Surg. (2009) 9:141–3. doi: 10.1510/icvts.2009.205849 18. Nachtnebel A, Stöllberger C, Ehrlich M, Finsterer J. Aortic dissection after sildenafil-induced erection. South Med J. (2006) 99:1151–2. doi: 10.1097/01.smj.0000240732.65859.aa 19. Suleman S, Woliyi A, Woldemichael K, Tushune K, Duchateau L, Degroote A, et al. Pharmaceutical regulatory framework in ethiopia: a critical evaluation of its legal basis and implementation. Ethiop J Health Sci. (2016) 26:259–76. doi: 10.4314/ejhs.v26i3.9 20. Gebretekle GB, Serbessa MK. Exploration of over the counter sales of antibiotics in community pharmacies of Addis Ababa, Ethiopia: pharmacy professionals' perspective. Antimicrob Resist Infect Control. (2016) 5:2. doi: 10.1186/s13756-016-0101-z 21. Jackson G, Montorsi P, Cheitlin MD. Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective. Urology. (2006) 68(3 Suppl):47–60. doi: 10.1016/j.urology.2006.05.047 22. Kloner RA, Jackson G, Emmick JT, Mitchell MI, Bedding A, Warner MR, et al. Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men. J Urol. (2004) 172(5 Pt 1):1935–40. doi: 10.1097/01.ju.0000142687.75577.e4 23. Ethiopia CC. Summary and Statistical Report of the 2007 Population and Housing Census. Addis Ababa: Federal Democratic Republic of Ethiopia population Census Commission (2008). 24. Ausó E, Gómez-Vicente V, Esquiva G. Visual side effects linked to sildenafil consumption: an update. Biomedicines. (2021) 9:291. doi: 10.3390/biomedicines9030291 25. Gebreslassie M, Feleke A, Melese T. Psychoactive substances use and associated factors among Axum University students, Axum Town, North Ethiopia. BMC Public Health. (2013) 13:693. doi: 10.1186/1471-2458-13-693 26. Lindsey WT, Stewart D, Childress D. Drug interactions between common illicit drugs and prescription therapies. Am J Drug Alcohol Abuse. (2012) 38:334–43. doi: 10.3109/00952990.2011.643997 27. Murtadha M, Raslan MA, Fahmy SF, Sabri NA. Changes in the pharmacokinetics and pharmacodynamics of sildenafil in cigarette and cannabis smokers. Pharmaceutics. (2021) 13:876. doi: 10.3390/pharmaceutics13060876
    At Yale Medicine, we take a multidisciplinary approach to determine the underlying causes of your erectile dysfunction, and we understand the relationship between erectile dysfunction and other health issues. We regularly collaborate with colleagues across different areas of medicine to help patients who we treat.

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    Inadequate production of testosterone is not a common cause of erectile dysfunction. But, when ED does occur due to decreased testosterone production, testosterone replacement therapy may improve the problem.

    Life-changing problems or even everyday stress can trigger erectile dysfunction. Talking about these things with a licensed therapist can ease sexual anxiety and help you feel more confident in your relationship.
    Treatment is only indicated if both partners are troubled by the impotence and they have realistic expectations of what can be achieved by any treatment

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    Your doctor will do a physical exam and ask you questions about your symptoms. He or she may do a blood or urine test. Your doctor may consider other tests to rule out other conditions.

    Therefore, men with these health conditions should not use vardenafil without having these conditions evaluated and stabilized first. For example, men with uncontrolled high blood pressure should have their blood pressure controlled; and men with potentially life-threatening abnormal heart rhythms should have these rhythms controlled.
    These oral medications fit in the phosphodiesterase-5 inhibitors (also called PDE-5 or PDE inhibitors). They allow the man to have an erection, but they do not work as well for maintaining an erection.

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    Lydston, G. F. (1908) The surgical treatment of impotency. American Journal of Clinical Medicine, 15, 71–73.Google Scholar

    Tadalafil (Cialis) is the third oral medicine approved by the U.S. FDA for the treatment of erectile dysfunction. Like sildenafil (Viagra) and vardenafil (Levitra), tadalafil inhibits PDE5 (as described earlier). Unlike the other PDE 5 inhibitors, patients should take tadalafil once daily which is approved for the treatment of BPH (benign enlargement of the prostate).
    These drugs work in response to sexual stimulation and must be taken at least half an hour to two hours before sexual activity. Drawbacks include a loss of spontaneity and cost. In addition, high-fat meals can delay the onset of action. A vacuum erection device Urethral suppositories Penile injections

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To properly strengthen them, leading academic medical centre Mayo Clinic recommends doing three sets of 10 repetitions daily.

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ED is a potentially treatable medical condition and is not related to masculinity or sexual prowess. Men who have ED symptoms should consult with a doctor.

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Problems with the veins that drain the penis can also contribute to erectile dysfunction. If the veins are not adequately compressed, blood can drain out of the penis while blood is coming into the penis and this prevents a fully rigid erection and maintaining an erection. Venous problems can occur as a result of conditions that affect the tissue that the veins are compressed against, the tunica albuginea. Such conditions include Peyronie's disease (a condition of the penis associated with scarring [plaques] in the tunica albuginea that may be associated with penile curvature, pain with erections, and ED), older age, diabetes mellitus, and penile trauma (penile fracture).

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A vacuum device can be cumbersome. It also will hinder spontaneity. The elastic ring may lead to skin irritation, bruising, loss of feeling or sensitivity, or pain.

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